| 摘要 |
A compound having the formula (I) wherein: L is hydrogen; C1-6alky or substituted with one or two substituents selected from the group consisting of hydroxy, C1-4alkyloxy, C1-4alkyloxycarbonyl, mono and di (C1-4alkyl) amino, aryl and Hert2; C3-6alkenyl; C3-6alkenyl substituted with aryl; C1-6alkylcarbonyl; C1-6alky! oxycarbonyl; piperidyl; piperidyl substituted with C1-4alkyl or arylC1 4alkyl; C1-6alkylsulfonyl or arylsulfonyl; -A-B-is a bivalent radical of formula:-CR4=CR5- (a-1); or- CHR4-CHR5- (a-2); D is O or NR6; Q is a radical of the formula (b-1), (b-2) or (b-3); R' is hydrogen or C1-4alkyl ; or R' and R2 together may form a bivalent radical of formula- (CH2)m- wherein m is 1, 2,3 or 4; R2 ís hydrogen; halo; C1-6alkyl; trifluoromethyl; C3-6cycloalkyl; carboxyl; C1-4alkyloxycarbonyl; C3-6cycloalkylaminocarbonyl; aryl; Het1 ; or C1-6alkyl substituted with cyano, amino, hydroxy, C1-4alkylcarbonylamino, aryl or Het1 ; or R2 is a radical of formula:-O-R9 (c-1); or-NH-R10 (c-2); R3 is hydrogen, halo, hydroxy, C1-6alkyl or C1-6alkyloxy; or R2 and R3 taken together may form a bivalent radical of formula : - (CH2)n-(d-1); -CH2-CH2-O-CH2-CH2- (d-2); -CH2-CH2-N (R11)-CH2-CH2- (d-3); or -CH2-CH=CH-CH2- (d-4); wherein n is 2,3,4 or 5. The compounds fine use in treating atopic or asthmatic diseases.
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