ALPHA V INTEGRIN RECEPTOR ANTAGONISTS

摘要

The present invention relates to novel nonanoic acid derivatives, their synthesis, and their use as alphaV integrin receptor antagonists. The compounds and their pharmaceutically accepted salts have the formula where X is selected from and the remaining substituents have meanings given in the description. The compounds are antagonists of the integrin receptors AlphaV beta 3 and alphaV beta5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral diseases, cancer, and metastatic tumor growth. 41 claims