SINGLE-STRAND ANTIBODY WITH IMPROVED STABILITY

摘要

A single-strand antibody is disclosed, characterised in that the C- or N-terminus of the VH domain is connected to the N- or C-terminus of the VL domain, without a linker, whereby the VH domain comprises a deletion of at least one amino acid normally occurring at the C- or N-terminus thereof and/or the VL domain comprises a deletion of at least one amino acid normally occurring at the N- or C-terminus thereof, preferably with merely the VH domain of the single strand antibody comprising a deletion of the amino acid normally forming the C-terminus. A markedly improved stability of the antibody on storage can thus be achieved and also an improved half-life time in plasma is achieved.