DIHYDROCERAMIDE DESATURASE INHIBITORS.

摘要

The invention relates to derivatives of cyclopropenylceramide used as desaturase inhibitors characterised by the general formula I, wherein R1 may be an alkyl, alkenyl, alkynyl, aryl or any heterocyclic group, n can have any value whatsoever, be branched or not and contain unsaturations, and R2 and R3 can have the same or different values, represent aryl, heteroaryl, alkyl or acyl groups with one or more unsaturations in the chain, which may be branched or not and substituted by OH groups. The members of this new class of compounds have demonstrated an extraordinary activity as inhibitors of dihydroceramide desaturase and of ceramide biosynthesis and are useful for the treatment of pathologies associated with increases in intracellular ceramide levels.