THIA- AND OXAZOLES AND THEIR USE AS PPARS ACTIVATORS

摘要

A compound of formula (I) or pharmaceutically acceptable salts and solvates thereof. R1 and R2 are independently H or C1-3alkyl, m is 0-3; X<1> is NH, NCH3, O, S; R<3>, R<4> and R<5> are independently H, CH3, CF3, OCH3, allyl or halogen; X<2> is (CR<10>R<11>)n wherein n is 1 or 2; R<10> and R<11> independently represent H, fluorine or C1-16alkyl; R<26> and R<27> are independently H, C1-3 alkyl or R<26> and R<27> together with the carbon atom to which they are bonded form a 3-5 membered cycloalklyl ring. R<6> and R<7> independently represent H, fluorine or C1-16alkyl; R<9> is C1-6alkyl or CF3; One of Y and Z is N, the other is S or O; Each R<8> independently represents CF3, OCH3, CH3 or halogen; y is O, 1, 2, 3, 4, 5. Use of a compound of formula (I) for the manufacture of a medicament for the prevention or treatment of a hPPAR mediated disease or condition, such as dyslipidemia, syndrome X, heart failure, hypercholesteremia, cardiovascular disease, type II diabetes mellitus, type 1 diabetes, insulin reistance hyperlipidemia, obesity, anorexia bulimia, inflammation and anorexia nervosa.