发明名称 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
摘要 |
The present invention provides the enzyme and enzymatic procedures for cleaving the beta secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
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申请公布号 |
US2002081634(A1) |
申请公布日期 |
2002.06.27 |
申请号 |
US20010681442 |
申请日期 |
2001.04.05 |
申请人 |
GURNEY MARK E.;BIENKOWSKI MICHAEL J.;HEINRIKSON ROBERT L.;PARODI LUIS A.;YAN RIQIANG |
发明人 |
GURNEY MARK E.;BIENKOWSKI MICHAEL J.;HEINRIKSON ROBERT L.;PARODI LUIS A.;YAN RIQIANG |
分类号 |
C07K14/47;C12N5/02;C12N5/08;C12N9/64;C12Q1/37;(IPC1-7):G01N33/567;C12Q1/68 |
主分类号 |
C07K14/47 |
代理机构 |
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