发明名称 New metallkoprotease inhibitors, a process for their preparation and pharmaceutical compositions containing them
摘要 5-Sulfonyl-2-(4-pyridinyl)-benzofuran, benzothiophene or indole derivatives (I), containing a hydroxamic acid function, are new. Benzofuran, benzothiophene or indole derivatives of formula (I) and their isomers, N-oxides and acid or base addition salts are new. R1 = H, halo, 1-6C alkyl or 1-6C alkoxy; X = O, S or NR; R = H or 1-6C alkyl; A = N-hydroxy-carboxamido-substituted tetrahydrofuropyridine, thiomorpholine or tetrahydropyranylmethyl group of formula (i)-(iii); Ra = H, halo, 1-6C alkyl or 1-6C alkoxy; Rb, Rc = H or 1-6C alkyl; and n = 0-2. An Independent claim is also included for the preparation of (I).
申请公布号 AU9744201(A) 申请公布日期 2002.06.27
申请号 AU20010097442 申请日期 2001.12.21
申请人 LES LABORATORIES SERVIER 发明人 GUILLAUME DE NANTEUIL;ALAIN BENOIST;PHILIPPE PASTOUREAU;MASSIMO SABATINI;JOHN HICKMAN;ALAIN PIERRE;GORDON TUCKER
分类号 C07D491/048;A61K31/4433;A61K31/444;A61K31/541;A61P9/10;A61P19/02;A61P29/00;A61P35/00;A61P43/00;C07D405/14;C07D417/14;C07D491/04 主分类号 C07D491/048
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