HUMAN PROTEASE AND USE OF SUCH PROTEASE FOR PHARMACEUTICAL APPLICATIONS AND FOR REDUCING THE ALLERGENICITY OF NON-HUMAN PROTEINS

摘要

The present invention relates to a method of producing novel improved protein mutant which produce low allergenic response in humans compared to the parent of that mutant. Specifically, the present invention comprises neutralizing or reducing the allergenicity of a protein by introducing therein as replacement or modification of an epitope on such protein a sequence from human subtilisin.