| 摘要 |
The invention provides isolated nucleic acids molecules, designated TR-1 nucleic acid molecules, which encode novel transient receptor potential channel molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TR-1 gene has been introduced or disrupted. The invention still further provides isolated TR-1 polypeptides, fusion polypeptides, antigenic peptides and anti-TR-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
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