发明名称 METHODS OF USE OF BETA 1-INTEGRIN INHIBITORS
摘要 The present invention provides methods that use agents capable of one or more of the following: inhibiting leukocyte mediated destruction of tissues, especially after injuries to tissue due to heat or cold (i.e., burns or frostbite), light, electricity, chemicals, or other agents that cause tissue injury and destruction; inhibiting leukocyte mediated destruction of tissues after myocardial infarction, CNS ischemic injury (e.g., stroke), angioplasty, surgical incisions, injury-mediated trauma, and transplant reperfusion; inhibiting angiogenesis; inhibiting cancer cell metastasis, motility, and/or migration within tissue; restoring and/or potentiating the induction of programmed cell death in cancerous tissues or restoring normal cellular phenotype to cancerous tissue; inhibiting osteoclast adhesion and bone resorption; and/or inhibiting stem cell adhesion to bone marrow.
申请公布号 WO0056350(A9) 申请公布日期 2002.06.27
申请号 WO2000US07680 申请日期 2000.03.22
申请人 REGENTS OF THE UNIVERSITY OF MINNESOTA;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;SENTRON MEDICAL, INC.;MCCARTHY, JAMES, B.;MILESKI, WILLIAM, J.;JAMIESON, GORDON, A., JR.;LOW, WALTER, C.;SAWCHUK, RONALD, J.;FURCHT, LEO, T. 发明人 MCCARTHY, JAMES, B.;MILESKI, WILLIAM, J.;JAMIESON, GORDON, A., JR.;LOW, WALTER, C.;SAWCHUK, RONALD, J.;FURCHT, LEO, T.
分类号 A61K38/39;A61P9/00;A61P17/00;A61P19/00;A61P25/00;A61P29/00;A61P35/00;A61P41/00;(IPC1-7):A61K38/06;A61K38/07;A61K38/08 主分类号 A61K38/39
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