| 发明名称 |
REDUCING THE IMMUNOGENICITY OF ALLOGRAFTS |
| 摘要 |
There is provided an ex vivo method for reducing the immunogenicity of a tissue or organ prior to transplantation, comprising:
(a) establishing the tissue or organ in a warm perfusion system capable of supporting oxidative metabolism of the tissue or organ;(b) perfusing the tissue or organ with a warm non-blood perfusion solution for at least 1 hour to allow passenger leukocytes within the tissue or organ to migrate from the tissue or organ into the recirculating perfusion solution;(c) isolating the passenger leukocytes from the recirculating perfusion solution to prevent the passenger leukocytes from re-entering the tissue or organ. |
| 申请公布号 |
US2016160176(A1) |
申请公布日期 |
2016.06.09 |
| 申请号 |
US201514879637 |
申请日期 |
2015.10.09 |
| 申请人 |
BRASILE Lauren |
发明人 |
BRASILE Lauren |
| 分类号 |
C12N5/00;C12N5/078;A01N1/02 |
主分类号 |
C12N5/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An ex vivo method for reducing the immunogenicity of a tissue or organ prior to transplantation, comprising:
(a) establishing the tissue or organ in a warm perfusion system capable of supporting oxidative metabolism of the tissue or organ; (b) perfusing the tissue or organ with a warm non-blood perfusion solution for at least 1 hour to allow passenger leukocytes within the tissue or organ to migrate from the tissue or organ into the recirculating perfusion solution; (c) isolating the passenger leukocytes from the recirculating perfusion solution to prevent the passenger leukocytes from re-entering the tissue or organ. |
| 地址 |
Albany NY US |
