发明名称 |
Redirection of cellular immunity by protein-tyrosine kinase chimeras |
摘要 |
Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. The chimeric receptor includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent, and (b) an intracellular portion of a protein-tyrosine kinase which is capable of signalling the therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.
|
申请公布号 |
US6410014(B1) |
申请公布日期 |
2002.06.25 |
申请号 |
US19990333636 |
申请日期 |
1999.06.15 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
SEED BRIAN;ROMEO CHARLES;KOLANUS WALDEMAR |
分类号 |
C12N15/09;A61K35/12;A61K35/14;A61K38/00;A61K48/00;C07K14/705;C07K14/725;C07K14/73;C07K14/735;C07K19/00;C12N5/08;C12N5/10;C12N9/12;C12N15/62;C12N15/863;(IPC1-7):A61K48/00;C12N5/00;C12N15/63;C07H21/04;A01N63/00 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|