| 摘要 |
(+)-Cis-3-(acetoxy)-5-[2-(dimethylamino)-ethyl]-2,3-dihydro-2-(4- methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydroch- loride is prepared by N-alkylation of (+)-cis-3-hydroxy-2,3-dihydro-2-(4- methoxyphenyl)-1,5-benzothiazepin-4(5H)-one with di- methylaminoethyl chloride and- K2CO3 in toluene/water, addition of a solubilizing agent and in the presence of a phase- transfer catalyst, the toluene phase being directly subjected to the final O - acetylation.
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