发明名称 Compositions having neuroprotective and analgesic activity
摘要 Compounds of the formula:wherein R1 and R2 are alkyl of 1-8 carbons have been shown to have both neuroprotective and analgesic activities. The compounds of the invention may be used in treatment of conditions that would normally result in neuronal damage, including those arising on account of cerebral ischemia/hypoxia or increase in intracranial pressure such as neoplasms, stroke, meningitis or trauma and for treatment of pain. Compositions of the invention can also be useful for treatment of toxin-related damage such as drug over-dose or exposure to toxins in the environment.
申请公布号 US6410537(B1) 申请公布日期 2002.06.25
申请号 US20000541431 申请日期 2000.04.03
申请人 THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY 发明人 TORTELLA FRANK C.;DECOSTER MARK A.;RICE KENNER C.;CALDERON SYLVIA N.
分类号 A61K31/4965;(IPC1-7):A61K31/395;A61K31/495 主分类号 A61K31/4965
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