| 发明名称 |
Inhibitors of prenyl-protein transferase |
| 摘要 |
The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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| 申请公布号 |
US6410534(B1) |
申请公布日期 |
2002.06.25 |
| 申请号 |
US19990347673 |
申请日期 |
1999.06.29 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
DINSMORE CHRISTOPHER J.;BELL IAN M.;BESHORE DOUGLAS C.;WILLIAMS THERESA M. |
| 分类号 |
C07D498/08;A61K31/337;A61K31/415;A61K31/4188;A61P9/00;A61P9/10;A61P13/12;A61P27/02;A61P31/10;A61P31/12;A61P31/14;A61P35/00;A61P43/00;C07D498/04;C07D515/08;(IPC1-7):A61K31/418;C07D487/08 |
主分类号 |
C07D498/08 |
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