| 发明名称 |
Production of thrombin inhibitors |
| 摘要 |
A method for the production and secretion of proteins with hirudin activity in an eukaryotic host organism is provided. There are also provided hybrid vectors comprising a DNA sequence encoding a signal peptide upstream of and in reading frame with the structural gene for desulphatohirudin, and eukaryotic host organisms transformed with said hybrid vectors.
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| 申请公布号 |
US6410272(B1) |
申请公布日期 |
2002.06.25 |
| 申请号 |
US19900488513 |
申请日期 |
1990.02.27 |
| 申请人 |
CIBA-GEIGY CORPORATION A CORP. OF NEW YORK;NOVARTIS AG |
发明人 |
MEYHACK BERND;MAERKI WALTER;HEIM JUTTA |
| 分类号 |
A61K38/00;C07K;C07K14/815;C12N9/16;C12N9/26;C12N15/00;C12N15/70;C12N15/81;C12N15/90;C12P;(IPC1-7):C12P21/04 |
主分类号 |
A61K38/00 |
| 代理机构 |
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