Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses

摘要

The present invention relates to novel amidomethyl-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.

主权项

1. A method for the treatment of a disease selected from the group consisting of depressive disorders, childhood onset mood disorders, anxiety disorders, and stress-dependent anxiety disorders, the method comprising administering to a subject in need thereof a compound of formula (I) in which R1 is hydrogen, methoxy or ethoxy; R2 is hydrogen or methoxy; R3 is hydrogen, methyl, ethyl, n-propyl or isopropyl; X1 and X2 are N or CH, with the proviso that X1 and X2 are not simultaneously N; a racemate, or an enantiomer, or a pharmaceutically acceptable salt thereof.