发明名称 |
Transgenic animal expressing hla-a24 and utilization thereof |
摘要 |
The present invention relates to a non-human transgenic mammal which has had an HLA-A24 gene introduced and in which CTLs are induced when stimulated by an HLA-A24-binding antigen. Such a transgenic mammal provides a method of screening therapeutic or preventive agents for tumors or virus infections by administering a test substance to the transgenic animal and evaluating whether CTLs specific for the test substance are induced. An HLA-A24-binding tumor antigen peptide of PSA origin that is selected by this screening method is described, as are a chimera DNA (DNA construct) useful in the generation of a non-human transgenic mammal, and a host cell transformed by the chimera gene and use thereof. |
申请公布号 |
AU2261002(A) |
申请公布日期 |
2002.06.24 |
申请号 |
AU20020022610 |
申请日期 |
2001.12.12 |
申请人 |
SUMITOMO PHARMACEUTICALS COMPANY, LIMITED |
发明人 |
MASASHI GOTOH |
分类号 |
A01K67/027;A61P31/12;A61P35/00;A61P43/00;C07K14/74;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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