CATECHOL THIAZOLIDINONE DERIVATIVE

摘要

PURPOSE: A catechol thiazolidinone derivative is provided, which compound can inhibit the activity of phosphodiesterase IV, and is thus useful for the treatment of diseases associated with phosphodiesterase IV. CONSTITUTION: The catechol thiazolidinone derivative capable of inhibiting the activity of phosphodiesterase IV represented by the following formula, its optical isomers and geometric isomers, and its pharmaceutically acceptable salts are provided, wherein R1 is C1-C2 alkyl or C1-C2 halogenated alkyl; R2 is C1-C7 alkyl or C3-C7 cycloalkane; R3 is C1-C7 alkyl, C1-C7 halogenated alkyl, C1-C7 alkanol, -(CH2)n phenyl, -(CH2)n pyridyl, -(CH2)n piperidyl, -(CH2)n pyrrolyl, -(CH2)n pyrimidyl, -(CH2)n pyrimidyl, -(CH2)n piperazyl, -(CH2)nCO2H, -(CH2)nNR2(R=alkyl), -(CH2)nCO2R(R=alkyl) or (CH2)nCONR2(R=alkyl); and n is 0 to 5.