SPIRO COMPOUND

摘要

PROBLEM TO BE SOLVED: To provide a new spiro compound useful as a prophylactic and therapeutic agent for central nervous system diseases based on nociceptin receptor- binding action. SOLUTION: This spiro compound is represented by the general formula (I) [wherein ring A1 and ring A2 are each an optionally substituted benzene ring; E is a divalent chain hydrocarbon group which may be substituted; X is CO or the like; R1 is an optionally substituted hydrocarbon group or the like, or alternatively R1 may be bonded to a ring-constituting carbon atom of ring A2 to form a fused ring; and the symbol ... represents a single or double bond] or its salt.