| 发明名称 |
METHODS FOR MAKING APO-2 LIGAND USING DIVALENT METAL IONS. |
| 摘要 |
<p>Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.</p> |
| 申请公布号 |
MXPA01013236(A) |
申请公布日期 |
2002.06.21 |
| 申请号 |
MX2001PA13236 |
申请日期 |
2000.06.26 |
| 申请人 |
GENENTECH, INC. |
发明人 |
ASHKENAZI, AVI, J. |
| 分类号 |
B01J20/281;A61K9/00;A61K9/08;A61K9/19;A61K38/00;A61K47/02;A61P31/12;A61P35/00;B01J20/285;C07K14/525;C07K14/705;C12N1/21;C12N15/09;C12N15/19;C12P21/02;C12R1/19;G01N30/88;G01N30/96 |
主分类号 |
B01J20/281 |
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