COMPLEMENT-RESISTANT NON-MAMMALIAN DNA VIRUSES AND USES THEREOF

摘要

Disclosed are methods, nucleic acids, and cells for expressing an exogenous gene in a mammalian cell, involving (i) introducing into the cell a complement-resistant non-mammalian DNA virus (e.g., a baculovirus), optionally having an altered coat protein, the genome of which virus carries an exogenous, gene, and (ii) growingthe cell under conditions such that the gene is expressed.