Method for producing pluripotent stem cell having improved chimera forming ability from primed pluripotent stem cell, and composition and combination therefor

摘要

The present invention provides a method for putting a primed pluripotent stem cell in a less differentiated state, a method for producing a pluripotent stem cell having an improved chimera forming ability from a primed pluripotent stem cell, and a method for producing a chimeric animal by using the pluripotent stem cell obtained by any of these methods. The present invention also provides a composition containing a Wnt/β catenin signal inhibitor.

主权项

1. A method for putting a primed pluripotent stem cell in a less differentiated state, comprising placing a primed pluripotent stem cell in a state where a Wnt/β catenin signal is inhibited and a signal transducer and activator of transcription 3 (STAT3) signal is activated.