DITERPENE COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY DISEASE, IMMUNE DISEASE AND CANCER

摘要

PURPOSE: Provided are diterpene compounds useful for the treatment of inflammatory diseases, immune diseases and cancer. CONSTITUTION: A diterpene compound, kamebanin, represented by formula(1), a diterpene compound, kamebacetal A, represented by formula(2), a diterpene compound, kamebakaurin,represented by formula(3), and a diterpene compound, exisanin A, represented by formula(4) are and useful for treatment of inflammatory disease, immune disease and cancer. The diterpene compounds inhibit the activities of nitric oxide, prostaglandin, and TNF-alpha, as well as effectively inhibit the activities of an inflammation inducing factor and NF-kappa B associated with cell apoptosis. Therefore, a pharmaceutical compositions useful for the treatment of inflammatory diseases, immune diseases and cancer contains the diterpene compounds as active ingredients.