| 摘要 |
The present invention relates to pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, infectious diseases, neurodegeneratives diseases, and primary and metastatic neoplastic diseases. In the practice of the invention, the compositions are employed comprising: (a) a heat shock protein (hsp) or an alpha(2)macroglobulin ( alpha 2M); (b) a saponin; and, optionally, (c) an antigenic molecule. The antigenic molecule displays the antigenicity of an antigen of : (a) a cell that elicits an autoimmune response; (b) an agent of an infectious diseases; (c) a cancerous cell; or (d) a cell or structure associated with a neurodegenerative or amyloid disease. The hsps that can be used in the practice of the invention include but are not limited to hsp70, hsp90, gp96, calreticulin, hsp 110, grpl 170, and PDI, alone or in combination with each other. The antigenic molecule can be covalently or noncovalently bound to the hsp or alpha 2M, free iin solution, and/or covalently bound to the saponin. The compositions of the invention can be administered alone or in combination with the administration or antigen presenting cells sensitized with an hsp- or alpha 2M-antigenic molecule complex. |
