40322, a novel human dynamin

摘要

The present invention relates to a newly identified human dynamin belonging to the superfamily of mammalian GTPases. The invention also relates to polynucleotides encoding the dynamin. The invention further relates to methods using the dynamin polypeptides and polynucleotides as a target for diagnosis and treatment in dynamin-mediated or -related disorders. The invention further relates to drug-screening methods using the dynamin polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the dynamin polypeptides and polynucleotides. The invention further relates to procedures for producing the dynamin polypeptides and polynucleotides.