| 摘要 |
The present invention provides heretofore unidentified proteins and smaller peptides of HCV, which are produced by translation of the HCV core RNA through a frameshifting mechanism. In one embodiment the invention provides a protein that is about 125 to about 161 amino acids long depending on the HCV genotypes. The smaller peptides of the invention range in length from about 13 amino acids to over 50 amino acids. The invention also includes DNA sequences that encode the polypeptides of the invention, antibodies directed against the polypeptides of the invention, and therapeutic compositions including vaccines and anti-viral compositions. Additionally, the invention provides for methods for diagnosing, preventing and treating hepatitis C using the compounds and compositions of the invention.
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