| 摘要 |
An adenylate cyclase type VII protein, cDNA, and reagents which regulate human adenylate cyclase type VII can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, diseases that are caused by aberrant activity of this enzyme and diseases whose symptoms can be ameliorated by stimulating or inhibiting the activity of type VII adenylyl cyclase. Such diseases include, for example, diseases caused by allergic or inflammatory reaction, such as asthma, allergic rhinitis, atopic dermatitis, food allergy, contact allergy, hives conjunctivitis, vernal catarrh; autoimmune diseases, COPD, inflammatory bowel diseases, rheumatoid arthritis, osteoarthritis, sepsis/septic shock, systemic inflammatory response syndrome, polymyositis, dermatomyositis, polyarthritis nodosa, mixed connective tissue disease, Suoegren's syndrome, gout; and bacterial, fungal, and viral infections, among others. |
