| 摘要 |
organic chemistry, chemical technology. SUBSTANCE: invention describes methods of synthesis of 14-hydroxymorphinones including oxycodone, noroxymorphone, naltrexone by oxidation of normorphinone dienol acylates using an aqueous medium in the presence of a weak acid. Noroxymorphone is a key intermediate product used for synthesis of some analgetics and antagonists of narcotic substances. Also, invention describes novel intermediate compounds. EFFECT: improved methods of synthesis. 24 cl, 8 sch, 47 ex |
