发明名称 Enhanced protein thermostability and temperature resistance
摘要 Small heat shock proteins, e.g., Pyrococcus fuiosus (Pfu-sHSP), confer thermotolerance on cellular cultures and on proteins in cellular extracts during prolonged incubation at elevated temperature, demonstrating the ability to protect cellular proteins and maintain cellular viability under heat stress conditions. Such heat shock proteins are effective to combat enzymatic aggregation and intracellular precipitation during heat stress, and thereby enable enhancement of the utility and stability of enzymes in various applications, e.g., Taq polymerase in PCR applications, digestive enzymes in microbial degradative applications, etc.
申请公布号 US2002077459(A1) 申请公布日期 2002.06.20
申请号 US20010835909 申请日期 2001.04.16
申请人 UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE 发明人 ROBB FRANK T.;LAKSANALAMAI PONGPAN
分类号 C07K14/195;C12N9/96;C12Q1/68;(IPC1-7):C07H21/02;C07H21/04;C07K1/00;C07K14/00;C07K17/00;C12P19/34;C12N9/22 主分类号 C07K14/195
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