摘要 |
The VP60 structural antigen or a fragment thereof of rabbit hemorrhagic disease virus (RHDV) can be obtained in plants using a viral vector based on the plum pox virus (PPV), which includes a promoter, a recombinant DNA sequence including a cDNA to the genome of the PPV virus, full-length, and a DNA sequence which codes for the RHDV VP60 protein or a fragment thereof inserted between the nucleotide sequences coding the Nib and CP proteins of the PPV virus, and a cloning vehicle. The antigen obtained is capable of inducing protection in rabbits against a lethal challenge of RHDV, and can be used as a recombinant subunit vaccine against rabbit hemorrhagic disease virus. |
申请人 |
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS;FORT DODGE VETERINARIA, S.A.;FERNANDEZ, MARIA, D.;MOURINO, MERCEDES;RIVERA, TORRES, JOSE;RODRIGUEZ, FRANCISCO;PLANA, DURAN, JUAN;GARCIA, ALVAREZ, JUAN, ANTONIO |
发明人 |
FERNANDEZ, MARIA, D.;MOURINO, MERCEDES;RIVERA, TORRES, JOSE;RODRIGUEZ, FRANCISCO;PLANA, DURAN, JUAN;GARCIA, ALVAREZ, JUAN, ANTONIO |