SUBSTITUTED (1,3-BIS(CYCLOHEXYLMETHYL)-1,2,3,6-TETRAHYDRO- 2,6-DIOXO-9H-PURIN-8-YL)PHENYL DERIVATIVES,THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF INFLAMMATORY CONDITIONS AND IMMUNE DISORDERS

摘要

A compound of formula (I) or a solvate thereof wherein: X is -O- or -NH-; Q is (-CH2-)p, (-C=CH)p, (-CC-)p where p is an integer of from 0 to 4; R1 is hydrogen or methyl; R2 and R3 independently represent O or S; n is an integer of 1 to 50; and R is hydrogen or methyl. This series of complex esters and amides of selected phenyl xanthine derivatives inhibit the expression of adhesion molecules on human umbilical vein endothelial cell (HUVEC) monolayers at very low concentrations and which are therefore indicated for treatment of inflammatory conditions and immune disorders.