发明名称 |
Adenosine monophosphate deaminase crystal structure |
摘要 |
<p>A 2.2 ANGSTROM crystal structure of rabbit AMP deaminase, an integral enzyme of purine nucleotide interconversion, has been determined, in an unligated state and with an inhibitor bound. The present invention further discloses the use of x-ray crystallographic data for identification and construction of possible therapeutic compounds in the treatment of various disease conditions. The sequence of rabbit AMP deaminase is also disclosed. <IMAGE></p> |
申请公布号 |
EP1215587(A2) |
申请公布日期 |
2002.06.19 |
申请号 |
EP20010309996 |
申请日期 |
2001.11.29 |
申请人 |
PFIZER LIMITED;PFIZER INC. |
发明人 |
BAZIN, RICHARD J.;MCDONALD, GRAEME A.;PHILLIPS, CHRISTOPHER |
分类号 |
A61K45/00;C12N15/09;A61P9/00;A61P9/04;A61P9/10;A61P25/28;A61P11/00;A61P43/00;C12N9/78;C12N9/99;(IPC1-7):G06F17/00 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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