发明名称 |
PROTEIN/(POLY)PEPTIDE LIBRARIES |
摘要 |
The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries. |
申请公布号 |
EP0859841(B1) |
申请公布日期 |
2002.06.19 |
申请号 |
EP19960929278 |
申请日期 |
1996.08.19 |
申请人 |
MORPHOSYS AG |
发明人 |
KNAPPIK, ACHIM;PACK, PETER;GE, LIMING;MORONEY, SIMON;PLUECKTHUN, ANDREAS |
分类号 |
C12N15/09;C07K1/04;C07K14/47;C07K16/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/10;C12N15/13;C12N15/62;C12N15/70;C12P21/02;C40B40/02;G01N33/53 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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