发明名称 |
Method of detecting transmissible spongiform encephalopathies |
摘要 |
This invention provides an improved assays for the detection of transmissable spongiform encephalopathies (TSEs) in humans and non-human mammals. The methods involve detecting the presence or absence of 14-3-3 proteins in cerebrospinal fluid from the tested organism. Elevated levels of 14-3-3 are indicative of transmissable spongiform encephalopathies, in particular Cretzfeldt-Jacob disease in humans or mad cow disease in bovines).
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申请公布号 |
US6406860(B1) |
申请公布日期 |
2002.06.18 |
申请号 |
US19990326976 |
申请日期 |
1999.06.07 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
HSICH GARY;KENNEY KIMBRA;GIBBS, JR. CLARENCE J.;HARRINGTON MICHAEL G. |
分类号 |
G01N27/447;G01N33/68;(IPC1-7):G01N33/53;A61K49/00;A61K39/395;C12Q1/70 |
主分类号 |
G01N27/447 |
代理机构 |
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代理人 |
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地址 |
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