发明名称 |
Process for preparing polyvalent and physiologically degradable carbohydrate-containing polymers by enzymatic glycosylation reactions and the use thereof for preparing carbohydrate building blocks |
摘要 |
A process for preparing polyvalent, physiologically degradable carbohydrate-containing polymers by enzymatic glycosylation reactions is described. The carbohydrate-containing polymers thus prepared may be used for preparing carbohydrate building blocks. The polyvalent carbohydrate-containing polymers of the invention cause no intolerance reactions in vivo, either in their intact form or in the form of degradation products. The carbohydrate side chain of the carbohydrate-containing polymer is assembled by enzymatic glycosylation reactions in homogeneous aqueous buffer systems directly on a biodegradable polymer. The yields of the glycosylation reaction are significantly improved over known processes, and are often quantitative. This also provides a significant increase in the loading densities. A process for preparing free oligosaccharides by means of the carbohydrate-containing polymers of the invention is also described.
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申请公布号 |
US6406894(B1) |
申请公布日期 |
2002.06.18 |
申请号 |
US19970989136 |
申请日期 |
1997.12.11 |
申请人 |
GLYCOREX AB |
发明人 |
HOERSCH BRIGITTE;AHLERS MICHAEL;KRETZSCHMAR GERHARD;BARTNIK ECKART;SEIFFGE DICK |
分类号 |
A61K47/48;C07H3/06;C07H15/04;C07H15/203;C12P19/18;C12P19/26;C12P19/44;(IPC1-7):C12P19/18;C07H7/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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