COCAINE HAPTENS

摘要

The development of a catalytic monoclonal antibody (mAb) provides the means for not only binding, but also degrading cocaine, which offers a broad-based therapy for cocaine addition. Hapten design is the central element for programming antibody catalysis. The characteristics of the linker used in classic transition-state analog phosphonate haptens are shown to be important for obtaining mAbs that hydrolyze the benzoate ester of cocaine.