| 摘要 |
This invention provides a method of determining the proteolytic activity of the in vivo secretases, particularly the beta-secretease and gamma-secretease that produce the Abeta peptides found in the plaques of Alzheimer Dementia (AD) patients. The invention also provides methods of isolating such secretases and methods of selecting agents that affect the activity of such secretases for developing drugs to treat or prevent dementia.
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