DETECTION OF COMPOUNDS SUCH AS THYROXINE

摘要

A novel method, referred to as Simultaneous Multi-Analyte Capture Mass Spectrometry (SMAC-MS), is disclosed for the quantification of analytes, in particular thyroxine (T4) and 17- alpha -hydroxyprogesterone (17OHP) in dried blood spots of newborns for the purposes of mass screening and diagnosis of congenital hypothyroidism (CHT) and congenital adrenal hyperplasia (CAH). The method enables a high-throughput and automated process that will be fully integrated into neonatal screening programmes. The method may also be provided by a test kit to carry out the process.