RECOMBINANT AND MUTANT MAREK'S DISEASE VIRUS

摘要

The present invention provides methods and reagents for inducing active immunity in animals. In particular, the present invention provides recombinant herpesviruses having foreign DNA that are capable of inducing immunity to the herpesvirus and/or the source of the foreigh DNA. The present invention also provides mutant herpesviruses having portions of their genome deleted. Preferably, foreign DNA is introduced, or portions of the genome are deleted, in the UL54.5 open reading frame of avian herperviruses or the UL43 open reading frame of Marek's disease virus.