COMPOSITIONS FOR SUSTAINED DELIVERY OF HYDROPHOBIC DRUGS AND PROCESS FOR THE PREPARATION THEREOF

摘要

A composition for the sustained delivery of a drug comprising an amphiphilic diblock copolymer; a poorly water-soluble drug; a biodegradable polymer; and liquid poly(ethylene glycol) or functional derivatives thereof and a process for preparing the composition are disclosed. When administered into a particular body site, the composition forms an implant and the drug and polymeric micelles containing the same are slowly released from the implant to maintain a constant drug concentration for an extended period of time.