发明名称 |
N-benzenesulfonyl L-proline compounds as bradykinin antagonists |
摘要 |
<p>This invention provides a compound of the formula (I): <CHEM> or the pharmaceutically acceptable salts thereof wherein X<1> and X<2> are halo; R<1> and R<2> are independently hydrogen or C1-4 alkyl; R<3> and R<4> are each hydrogen or halo; and R<5> is (a) -C3-9 diazacycloalkyl optionally substituted with C5-11 azabicycloalkyl; (b) -C3-9 azacycloalkyl-NH-(C5-11 azabicycloalkyl optionally substituted with C1-4 alkyl); (c) -NH-C1-3 alkyl-C(O)-C5-11 diazabicycloalkyl; (d) -NH-C1-3 alkyl-C(O)-NH-C5-11 azabicycloalkyl, the C5-11 azabicycloalkyl being optionally substituted with C1-4 alkyl; (e) -C3-9 azacycloalkyl optionally substituted with C3-9 azacycloalkyl; or (f) -NH-C1-5 alkyl-NH-C(O)-C4-9 cycloalkyl-NH2. These compounds are useful for the treatment of medical conditions mediated by bradykinin such as inflammation, allergic rhinitis, pain, etc. This invention also provides a pharmaceutical composition comprising the above compound.</p> |
申请公布号 |
EP1213289(A1) |
申请公布日期 |
2002.06.12 |
申请号 |
EP20010310151 |
申请日期 |
2001.12.04 |
申请人 |
PFIZER INC. |
发明人 |
KATSU, YASUHIRO;KAWAI, MAKOTO;KOIKE, HIROKI;NUKUI, SEIJI |
分类号 |
A61K31/4709;A61K31/496;A61K31/4995;A61P1/16;A61P1/18;A61P3/10;A61P11/00;A61P11/02;A61P11/06;A61P13/10;A61P17/02;A61P19/02;A61P25/04;A61P25/28;A61P27/02;A61P27/06;A61P29/00;A61P31/02;A61P35/00;A61P37/06;A61P37/08;A61P43/00;C07D401/12;C07D401/14;C07D451/02;C07D451/04;C07D453/02;C07D487/08;C07D487/04;A61K31/46;(IPC1-7):C07D453/02;A61K31/395 |
主分类号 |
A61K31/4709 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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