发明名称 |
PROCESS FOR THE PREPARATION OF OPTICALLY PURE ISOMERS OF FORMOTEROL |
摘要 |
<p>A method is disclosed for the preparation of optically pure isomes of formeterol, especially the (R,R)- and (S,S)-isomer, by the reaction of an optically pure 4-benzyloxy-3-formamidostyrene oxide with an optically pure 4-methoxy- alpha -methyl-N-(phenylmethyl)benzeneethanamine followed by debenzylation. Useful intermediates in the process are also disclosed, as is the novel L-tartrate salt of R,R-formoterol.</p> |
申请公布号 |
EP0938467(B1) |
申请公布日期 |
2002.06.12 |
申请号 |
EP19970946623 |
申请日期 |
1997.11.07 |
申请人 |
SEPRACOR, INC. |
发明人 |
GAO, YUN;HETT, ROBERT;FANG, KEVIN, Q.;WALD, STEPHEN, A.;SENANAYAKE, CHRIS, H. |
分类号 |
B01J23/42;A61K9/00;C07B61/00;C07C205/37;C07C205/45;C07C213/02;C07C217/60;C07C217/86;C07C231/18;C07C233/25;C07C233/43;(IPC1-7):C07C231/18 |
主分类号 |
B01J23/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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