Process for preparing itaconate and succinate derivatives by olefination process

摘要

An efficient and selective process, capable of scale-up, to make itaconate derivatives of formula (IV), and/or succinate derivatives of formula (V) and/or (VI) by asymmetric hydrogenation of the itaconate derivatives. The process comprises formation of a compound of formula (IV) by reaction of an aldehyde of formula RCHO with a phosphorus compound of formula (IX): or a metal carboxylate optionally followed by, if a compound of formula (V) or (VI) is desired, asymmetric reduction of a compound of formula (IV) to provide a compound of formula (V) or (VI)