发明名称 |
Process for intercalation of spacer molecules between substrates and active biomolecules |
摘要 |
A wide variety of substrates can be functionalized to attach spacer molecules therein by exposing the substrates to a cold plasma ignited in dichlorosilane, silicon tetrachloride or hexachlorodisilane gas to implant silicon-chlorine functionalities in the substrate surface. The plasma implanted surface functionalities can then be utilized to initiate second stage gas phase derivatization reactions to form linker molecules attached to the substrate. Active biomolecules such as enzymes can then be bound to the exposed linker molecules to bind the bioactive molecules to the substrate while allowing freedom of movement and conformation of the bound molecule comparable to that of the free molecule.
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申请公布号 |
US6402899(B1) |
申请公布日期 |
2002.06.11 |
申请号 |
US20000492981 |
申请日期 |
2000.01.27 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
DENES FERENCZ S.;MANOLACHE SORIN O.;SARMADI MAJID;YOUNG RAYMOND A.;GANAPATHY RAMASWAMI;MARTINEZ-GOMEZ ALVARO DE JESUS |
分类号 |
C08J7/12;C12N9/76;C12N11/06;C12N11/14;(IPC1-7):B01J19/08 |
主分类号 |
C08J7/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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