发明名称 |
Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans |
摘要 |
A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting materials and intermediates are provided as well. An important application of the invention is in the synthesis of CMI-392, (±)trans-2-[5-N'-methyl-N'-hydroxyureidyl-methyl)3-methoxy-4-p-chlorophenylthioethoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran, a highly effective agent in treating inflammatory and immune disorders. The invention also encompasses novel compounds useful as starting materials and intermediates in the synthetic processes disclosed.
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申请公布号 |
US6403814(B1) |
申请公布日期 |
2002.06.11 |
申请号 |
US19990418637 |
申请日期 |
1999.10.15 |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
RAO ALLA VENKATA RAMA;CHORGHADE MUKUND S.;ISLAM AMIN UL;RAO VEMURI VENKATA KIRAN;PRASAD ANEGONDI SREENIVASA;RAO BATCHU VENKATESWARA;REDDY RANGA;REDDY LALATA KRISHNAKANTH;SHAILAJA KOTAKONDA;GURJAR MUKUND KESHAO;MHASKAR SUNIL VYANKATESH |
分类号 |
C07C45/63;C07C45/71;C07C319/20;C07C323/19;C07D307/12;C07D307/14;C07D307/16;(IPC1-7):C07D307/02 |
主分类号 |
C07C45/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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