摘要 |
The present invention provides allylic disulfone of Chemical Formula 1, an important intermediate which can be used for syntheses of retinoids and carotenoids, a process for preparing the same, and a process for preparing retinoid compounds by using the said intermediate, and, in particular, a process for preparing retinoic acid of Chemical Formula 2 and alkyl retinoate of Chemical Formula 3. The process for preparing allylic disulfone compound of Chemical Formula 1 employs cyclo-geranyl sulfone, which reacts with C5 haloallylic sulfide to give rise to the chain-extended C15 thio-sulfone compound. The thio-sulfone compound is selectively oxidized to give allylic disulfone of Chemical Formula 1. The C15 disulfone compound reacts with C5 halo-acid or C5 halo-ester under the condition using excess base, which induces coupling and subsequent desulfonation reactions to give retinoic acid of Chemical Formula 2 or alkyl retinoate of Chemical Formula 3. |