发明名称 |
COMPOUND OF HYDROXAMIC ACID DERIVATIVE AND HYALURONIC ACID |
摘要 |
A compound having MMP inhibitory activity which is a compound of a hydroxamic acid derivative represented by the following general formula (1) and hyaluronic acid: (1) wherein R1 represents hydrogen, hydroxy, C1-8 alkyl, etc.; R2 represents C1-8 alkyl, etc.; R3 represents C1-8 alkyl, etc.; R4 represents hydrogen or C1-4 alkyl; R5 represents -R7-R8-R9-, where R7 represents C1-8 alkylene, R8 represents methylene, imino, oxygen, etc., and R9 represents C1-10 alkylene, etc.; and R6 represents hydrogen or C1-4 alkyl, provided that R1 and R3 in combination may form a ring. The compound comprises a group represented by the formula (1) and any of hyaluronic acid, a derivative thereof, and salts of these, the former being bonded to a hydroxyl group of the latter through a carbamate linkage.
|
申请公布号 |
WO0244218(A1) |
申请公布日期 |
2002.06.06 |
申请号 |
WO2001JP10493 |
申请日期 |
2001.11.30 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA;DENKI KAGAKU KOGYO KABUSHIKI KAISHA;IKEYA, HITOSHI;MORIKAWA, TADASHI;TAKAHASHI, KOICHI;OKAMACHI, AKIRA;TAMURA, TATSUYA |
发明人 |
IKEYA, HITOSHI;MORIKAWA, TADASHI;TAKAHASHI, KOICHI;OKAMACHI, AKIRA;TAMURA, TATSUYA |
分类号 |
A61K31/728;A61P19/02;A61P29/00;A61P43/00;C08B37/08;(IPC1-7):C08B37/08 |
主分类号 |
A61K31/728 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|