发明名称 |
Non-aqueous surfactant-containing formulations for extended release of somatotropin |
摘要 |
The present invention provides compositions comprising biologically-active somatotropin formulated for extended release and methods of preparing and methods of using the same. These compositions comprise somatotropin, at least a first bioavailability-enhancing constituent (BEC), and a substantially non-aqueous, hydrophobic excipient, and optionally a second BEC. The first BEC is typically a surfactant (preferably a non-ionic surfactant) or a cyclodextrin compound. The optional second BEC may comprise (i) amino acids or amino acid derivatives; (ii) hydroxamate derivatives; (iii) non-reducing carbohydrates; (iv) oxo-acid salts; or (v) a mixture of two or more compounds from within the foregoing classes (i)-(iv).
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申请公布号 |
US2002068693(A1) |
申请公布日期 |
2002.06.06 |
申请号 |
US20010891445 |
申请日期 |
2001.06.26 |
申请人 |
JENG YUNHUA N.;PATEL KANAIYALAL R. |
发明人 |
JENG YUNHUA N.;PATEL KANAIYALAL R. |
分类号 |
A61K9/00;A61K9/107;A61K38/17;A61K47/10;A61K47/26;(IPC1-7):A61K38/22;A61K31/70;A61K31/724 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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