发明名称 |
RECEPTOR-MEDIATED UPTAKE OF PEPTIDES THAT BIND THE HUMAN TRANSFERRIN RECEPTOR |
摘要 |
Peptides have been discovered which are capable of binding to and internalizing with the human transferrin receptor (hTfR). The sequences HAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2) are capable of binding to and internalizing with the human transferrin receptor. When these molecules were fused with other molecules, the fusion product was internaliz ed in cells expressing hTfR. The sequences have use for targeting other peptide s and proteins into cells expressing hTfR.
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申请公布号 |
CA2449412(A1) |
申请公布日期 |
2002.06.06 |
申请号 |
CA20012449412 |
申请日期 |
2001.11.29 |
申请人 |
UAB RESEARCH FOUNDATION |
发明人 |
COLLAWAN, JAMES;MOORE, BRYAN;LEE, JAE, HWY;ENGLER, JEFFREY |
分类号 |
A61K47/48;C07K7/06;C07K7/08;C12N15/10;C40B40/02;(IPC1-7):C12N15/62;C07K19/00;C12N15/11 |
主分类号 |
A61K47/48 |
代理机构 |
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